Quantcast

Search Content Library



Search Language
Browse
Medical Illustrations
Medical Charts
Tear Sheet Pads
Medical Animations
Medical Animation Titles
Medical Encyclopedia
Custom Interactive
Most Recent Uploads
Body Systems/Regions
Anatomy & Physiology
Cells & Tissues
Cardiovascular System
Digestive System
Lymphatic System
Integumentary System
Muscular System
Nervous System
Reproductive System
Respiratory System
Skeletal System
Special Senses
Urinary System
Abdomen
Back and Spine
Foot and Ankle
Head and Neck
Hip
Knee
Shoulder
Thorax
Medical Specialties
Cancer
Cardiology
Dentistry
Editorial
Health & Fitness
Neurology/Neurosurgery
Ob/Gyn
Orthopedics
Pathology
Pediatrics
Account
Administrator Login
Medication Absorption - Medical Animation
 
If animation does not play, download and install the latest free Flash Player plugin.
More Like ThisAdd To Lightbox ANM11011 Elite  Enlarge Share
Animation licenses start at $350/year

Item #ANM11011Source #1029

Medication Absorption - Medical Animation
MEDICAL ANIMATION TRANSCRIPT:
Medication absorption is the movement of a drug from its site of administration into the blood. Oral drugs enter the stomach where they either dissolve and pass through the cell membranes of epithelial cells lining the stomach or travel undissolved through the stomach to the small intestine, which is the most common site of absorption. Here, drugs dissolve and pass through the intestinal wall. Oral drugs then travel through the portal venous system to the liver, where they undergo the first pass effect. During this process, the liver metabolizes some of the drug, either inactivating it or excreting it into bile for elimination from the body. The remaining amount of active drug leaves the liver and reaches general circulation and target organs. If a drug is administered via intravenous injection, it passes directly into the bloodstream, thus bypassing absorption in the GI tract. If administered through intramuscular or subcutaneous injection, the drug enters either muscle or subcutaneous tissue, where it passes through gaps between cells into capillary walls and then into general circulation or target organs, also bypassing absorption in the GI tract. Bioavailability is the net amount of a dose of a drug that is actually absorbed into the bloodstream. The bioavailability of oral drugs is less than 100% because of the first pass effect of the liver. In contrast, the bioavailability of IV drugs is 100% because they are not exposed to the first pass effect of the liver. Different drug formulations alter bioavailability, because they are not absorbed at the same rate or to the same extent. For example, tablets dissolve at varying rates. Enteric coated drugs dissolve in the small intestine, not the stomach. Because gastric emptying time differs between individuals, absorption times also vary. Sustained release formulas contain tiny spheres that dissolve at different rates, resulting in a steady drug release throughout the day, but also resulting in variable absorption. Some factors affecting drug absorption are the rate of dissolution. Drugs that dissolve faster are absorbed faster. Surface area, since the lining of the small intestine has more surface area than the lining of the stomach, most drugs are absorbed faster in the small intestine. Blood flow, the greater the concentration gradient between the drug-filled stomach and the rapidly flowing drug-free blood, the faster the absorption. Lipid solubility, highly lipid soluble drugs pass through the phospholipids in the cell membrane more easily than drugs of low lipid solubility. And PH partitioning, absorption is faster when the difference between the PH at the site of administration and the PH of the plasma attracts more drug molecules to ionize in the plasma. ♪ [music] ♪

YOU MAY ALSO WANT TO REVIEW THESE ITEMS:
Peptic Ulcer
Peptic Ulcer - ANH11057
Medical Animation
Add to my lightbox
Find More Like This
Type 2 Diabetes
Type 2 Diabetes - ANH11055
Medical Animation
Add to my lightbox
Find More Like This
High Cholesterol Management
High Cholesterol Management - ANH15146
Medical Animation
Add to my lightbox
Find More Like This
Medication Distribution
Medication Distribution - ANM10008
Medical Animation
Add to my lightbox
Find More Like This
Pharmacodynamics - Pharmacokinectics
Pharmacodynamics - Pharmacokinectics - ANM11012
Medical Animation
Add to my lightbox
Find More Like This
Type 2 Diabetes
Type 2 Diabetes - ANM10005
Medical Animation
Add to my lightbox
Find More Like This
Nucleus | About Nucleus | Medical Review Board | Free Medical Images | Testimonials | Patient Education
Social Media Marketing Hospital | Pregnancy Videos | Credits | Contact Us | Find a Lawyer | Hospital Marketing